Translation of Human Globin mRNA: Globin Synthesis in Cells Containing Hb Leiden
نویسنده
چکیده
Most structurally abnormal hemoglobins are present in smaller amounts than HbA in the erythrocytes of heteroxygous subjects. In the presence of a hemoglobinopathy, a and globin synthesis remains balanced with equal production of the two types of chains. In reticulocytes of subjects with Hb Leiden (fi6 or 7 glu 0) there is greater production of a than fi globin in vitro (fl/a = 0.67), and slightly more $ is synthesized than L.Id.ii ( A/
منابع مشابه
Translation of human globin mRNA: globin synthesis in cells containing Hb Leiden.
Most structurally abnormal hemoglobins are present in smaller amounts than HbA in the erythrocytes of heterozygous subjects. In the presence of a hemoglobinopathy, alpha and beta globin synthesis remains balanced with equal production of the two types of chains. In reticulocytes of subjects with Hb Leiden (beta 6 or 7 glu leads to 0) there is greater production of alpha than beta globin in vitr...
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